Eric F. Schmidt, Stephen M. Strittmatter (auth.), R. J.'s Semaphorins: Receptor and Intracellular Signaling Mechanisms PDF

By Eric F. Schmidt, Stephen M. Strittmatter (auth.), R. J. Pasterkamp (eds.)

ISBN-10: 038770955X

ISBN-13: 9780387709550

ISBN-10: 0387709568

ISBN-13: 9780387709567

This ebook information our growth in realizing the receptor and intracellular signaling mechanisms used by a relations of proteins known as the semaphorins. initially those protein have been pointed out as "axon tips cues" vital for the formation of nerve tracts yet now it truly is discovered that semaphorins subserve a number of specified services in a large number of organ platforms.

This ebook summarizes our wisdom and makes it on hand as an invaluable and entire instrument for the clinical group. It covers the whole semaphorin box from neurosciences to cardiovascular study and past, detailing all of the newest strategies and effects. the great assessment of semaphorin biology and signaling awarded during this e-book permits one to match semaphorin services among assorted organic structures. The booklet may be of curiosity to humans operating within the box in addition to those that paintings in different fields of technology and wish to study extra approximately semaphorins and linked signaling mechanisms.

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Extra info for Semaphorins: Receptor and Intracellular Signaling Mechanisms

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64. Di Paolo G, Pellegrini L, Letinic K et al. Recruitment and regulation of phosphatidyHnositol phosphate kinase type 1 gamma by the FERM domain of talin. Nature 2002; 420(6911):85-89. 65. Aizawa H, Wakatsuki S, Ishii A et al. Phosphorylation of cofilin by LIM-kinase is necessary for semaphorin 3A-induced growth cone collapse. Nat Neurosci 2001; 4(4):367-373. 66. Pollard TD, Borisy GG. Cellular motility driven by assembly and disassembly of actin filaments. Cell 2003; 112(4):453-465. 67. Perrot V, Vazquez-Prado J, Gutkind JS.

As suggested for Plexin-Bl, Drosophila Plexin-B may sequester Racl and thereby suppress PAK activity. Genetic interactions suggests that the A-type C. elegans Plexin-1 acts to sense the level of RHO {rho-1) and RAC GTPases {mig-2 and ced-10) which determines the effect of semaphorins on the positioning of sensory ray \7^ Open Questions Although much progress has been made in dissecting the signaling cascades that mediate the effects of semaphorins and the role of GTPases in these pathways, we are still at the beginning to understand how activation of semaphorin receptors leads to growth cone collapse or changes in the trajectories of neurites.

J Cell Biol 2000; 149(2):411-422. 17. Bagnard D, Sainturet N, Meyronet D et al. Differential MAP kinases activation during semaphorin3A-induced repulsion or apoptosis of neural progenitor cells. Mol Cell Neurosci 2004; 25(4):722-731. 18. Basile JR, Afkhami T, Gutkind JS. Semaphorin 4D/plexin-Bl induces endothelial cell migration through the activation of PYK2, Src, and the phosphatidylinositol 3-kinase-Akt pathv^^y. Mol Cell Biol 2005; 25(16):6889-6898. 19. Brown M, Jacobs T, Eickholt B et al. Alpha2-chimaerin, cyclin-dependent Kinase 5/p35, and its target collapsin response mediator protein-2 are essential components in semaphorin 3A-induced growth-cone collapse.

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Semaphorins: Receptor and Intracellular Signaling Mechanisms by Eric F. Schmidt, Stephen M. Strittmatter (auth.), R. J. Pasterkamp (eds.)


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