C. Cooper (auth.), R. M. Francis MB, ChB, MRCP, W. Carson's Osteoporosis: Pathogenesis and Management PDF

By C. Cooper (auth.), R. M. Francis MB, ChB, MRCP, W. Carson Dick (eds.)

ISBN-10: 9401095809

ISBN-13: 9789401095808

ISBN-10: 9401095825

ISBN-13: 9789401095822

Osteoporosis is without doubt one of the most vital illnesses dealing with the getting older inhabitants end result of the excessive incidence of fractures, the large charges in future health care money required to accommodate the final result of those fractures, and the vast impact by way of ache and incapacity. One-third of ladies over age sixty five can have vertebral fractures, and the li fe-time danger ofhip fracture in white ladies (15%) is as nice as that ofbreast, endometrial, and ovarian melanoma mixed. The life-time probability of hip fracture in males (5%) is as nice because the threat of prostate melanoma. Hip fracture is deadly in as much as 20% of situations. One-half of survivors are not able to stroll unassisted and 25% are constrained to long term ca re in nursing hornes. the new expertise that osteo­ porosis is a treatable and in part preventable sickness of the aged, and never simply the inevitable outcome of getting older, comes at a time of fast development in size of bone mass and in a greater knowing of the body structure and pathophysiology of bone mobile function.

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1988). Are-evaluation of tartrate resistant acid phosphatase activity in rat calvarial osteoclasts. J. Bone Mineral Res. (In press). I!. Oursler, M. , Wilkemeyer, M. and Osdoby, P. (1987). Soluble bone factors induce osteoclast expression in vitro. J. , 2 (Suppl), 258. 12. , Louvard, D. and Courboy, P. J. (1985). Cell-mediated extracellular acidification and bone resorption: evidence for a low pH in resorbing lacunae and localisation of a 100 D lysosomal mem brane pro tein at the osteoclast ruffled border.

All these tissues contain haemopoietic elements. Osteoclasts and macrophages Although osteoclasts are of haemopoietic celllineage, it was thought for some time that the precursors were in fact identical to those for macrophages. The question of the relationship between macrophages and precursor osteoclasts has excited much controversy. Macrophages fuse together to form multinuclear giant cells with some characteristics similar to osteoclasts. In both cell types, maturation is enhanced by 1,25-dihydroxyvitamin D/O.

Eds), Osteoporosis 1. Proceedings ofthe Copenhagen International Symposium on Osteoporosis (Copenhagen: Glostrup Hospital), pp. 305-10. 48. , Blizzard, J. , Birkhead, N. C. and Rodahl, K. (1966). Effect of prolonged bed rest on urinary calcium output. J. Appl. , 21, 1013-20. 49. P. B. (1967). Bone demineralisation of foot and hand of Gemini-Titan IV, V and VII astronauts during orbital flight. Am. J. , 100, 503-11. 50. Jones, H. , Priest, J. , Hayes, W. , Tichenor, C. C. and Nagel, D. A. (1977).

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Osteoporosis: Pathogenesis and Management by C. Cooper (auth.), R. M. Francis MB, ChB, MRCP, W. Carson Dick (eds.)


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