Thomas Jue, Kazumi Masuda's Application of Near Infrared Spectroscopy in Biomedicine PDF

By Thomas Jue, Kazumi Masuda

ISBN-10: 1461462517

ISBN-13: 9781461462514

Based on the fashion of the guide of contemporary Biophysics, this fourth quantity, program of Near-Infrared Spectroscopy in Biomedicine, balances the necessity for actual science/mathematics formalism with a requirement for biomedical views. every one bankruptcy divides the presentation into significant elements: the 1st establishes the conceptual framework and describes the instrumentation or procedure, whereas the second one illustrates present purposes in addressing advanced biology questions. With the extra sections on additional interpreting, difficulties, and references, the reader can discover a few bankruptcy principles extra greatly.

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Extra resources for Application of Near Infrared Spectroscopy in Biomedicine

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The photon packet has a survival weight, which is related to light intensity. When the photon packet is scattered out of the head, the ultimate survival weight (W) is calculated from the absorption coefficient of each type of tissue (μa i) and the accumulated pathlength (Li) in each type of tissue Li: W ¼ W0 exp À N X ! 13) i¼1 where W0 is the survival weight of the photon packet reduced only by reflection on the boundary due to refractive index mismatch. There are other algorithms to determine successive scattering length and survival weight [22, 24].

The spatial sensitivity profile in the realistic head model is broadly distributed in the shallow region of the brain. Although the difference between realistic head model (a) and model (b) is only the optical properties of the CSF layer, the spatial sensitivity profile in model (b) is similar to that in homogeneous model (c). These results indicate that the low-scattering CSF layer has an influence on the spatial sensitivity profile in the brain. A comparison of mean optical pathlength for the head and partial optical pathlength in the brain as a function of probe spacing is shown in Fig.

The model was divided into small cubes, called cube “cells,” as shown in Fig. 4. Each cube was 1 mm  1 mm  1 mm in size. The mean path length of a cell was calculated by ∑(LiIi)/∑Ii, where Li is the path length of the ith photon in the cell and Ii is the final intensity of the ith photon at a detector. To focus on the spatial sensitivities in the x- and z-axis directions, the sensitivity values of the cell were summed up in the y-axis direction and illustrated. The distribution of sensitivities in the x-y plane at each layer was also obtained.

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Application of Near Infrared Spectroscopy in Biomedicine by Thomas Jue, Kazumi Masuda

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